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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CASP1 All Species: 8.79
Human Site: S209 Identified Species: 24.17
UniProt: P29466 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29466 NP_001214.1 404 45159 S209 V K K N L T A S D M T T E L E
Chimpanzee Pan troglodytes XP_001136115 404 45213 S209 V K K N L T A S D M T T E L K
Rhesus Macaque Macaca mulatta Q153Z0 421 47740 Q224 I E E N L T A Q E M E T A L R
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P29452 402 45622 L208 V K E N L T A L E M V K E V K
Rat Rattus norvegicus P43527 402 45557 L208 V K E N L T A L E M T K E L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509500 456 52101 T262 V E R N L S A T E M E S K L K
Chicken Gallus gallus Q98943 424 47941 E220 V F H D Q S A E E M E S A L E
Frog Xenopus laevis P55865 386 43644 A200 V K V M K E F A A Q E E H A D
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P42573 503 56598 Q209 S K A S G P T Q Y I F H E E D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.7 42.9 N.A. N.A. 61.6 62.1 N.A. 39.4 21.9 42 N.A. N.A. N.A. N.A. 24.4 N.A.
Protein Similarity: 100 99.5 60.8 N.A. N.A. 74.5 74 N.A. 57.2 42.4 58.4 N.A. N.A. N.A. N.A. 41.3 N.A.
P-Site Identity: 100 93.3 46.6 N.A. N.A. 53.3 66.6 N.A. 40 33.3 13.3 N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 100 73.3 N.A. N.A. 80 86.6 N.A. 93.3 60 26.6 N.A. N.A. N.A. N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 12 0 0 0 78 12 12 0 0 0 23 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 12 0 0 0 0 23 0 0 0 0 0 23 % D
% Glu: 0 23 34 0 0 12 0 12 56 0 45 12 56 12 23 % E
% Phe: 0 12 0 0 0 0 12 0 0 0 12 0 0 0 0 % F
% Gly: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 12 0 0 0 0 0 0 0 0 12 12 0 0 % H
% Ile: 12 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % I
% Lys: 0 67 23 0 12 0 0 0 0 0 0 23 12 0 45 % K
% Leu: 0 0 0 0 67 0 0 23 0 0 0 0 0 67 0 % L
% Met: 0 0 0 12 0 0 0 0 0 78 0 0 0 0 0 % M
% Asn: 0 0 0 67 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 12 0 0 23 0 12 0 0 0 0 0 % Q
% Arg: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 12 % R
% Ser: 12 0 0 12 0 23 0 23 0 0 0 23 0 0 0 % S
% Thr: 0 0 0 0 0 56 12 12 0 0 34 34 0 0 0 % T
% Val: 78 0 12 0 0 0 0 0 0 0 12 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _